colds

Cissus verticillata


(In territories with significant traditional TRAMIL use)

 Dominican Republic: bejuco caro
 Haiti: lyann mòl

Significant uses found by the TRAMIL surveys

  leaf, decoction with sugar, orally1

Recommandations
Preparation and posology
References

According to published and other information:

The topical use for abscess, ganglionar inflammation and boils is classified as REC, based on the significant traditional use documented in the TRAMIL surveys, and skin toxicity studies.

For topical application, strict hygiene measures should be observed in order to avoid contamination or additional infection.

Should there be a notable worsening of the patient’s condition, or should the abscess or boils last more than 5 days, seek medical attention.

Oral administration for cold, cough and influenza is classified as REC, based on the significant traditional use documented in the TRAMIL surveys and toxicity studies.

Not for use by women during pregnancy, during lactation or by children under 5 years old.

For abscess, ganglionar inflammation and boils:

Wash injury with boiled water and soap.  Apply the washed and crushed leaf in sufficient quantity to the affected area.  Cover the injury with a dressing or clean cloth.  Replace every 12 hours.

For colds, cough and influenza:

There is no available information establishing a means of preparation and dosage other than that referred to by traditional use.

1 WENIGER B, ROUZIER M, 1986 Enquête TRAMIL. Service Oecuménique d'Entraide SOE, Port au Prince, Haïti.

2 GERMOSEN-ROBINEAU L, GERONIMO M, AMPARO C, 1984 Encuesta TRAMIL. enda-caribe, Santo Domingo, Rep. Dominicana.

3 WENIGER B, SAVARY H, DAGUIHL R, 1984 Tri phytochimique de plantes de la liste TRAMIL. Laboratoire de chimie des substances naturelles, Faculté de Médecine et de Pharmacie, Université d'Etat d'Haïti, Port au Prince, Haïti.

4 PINEDA M, 1990 Fitoquímica de algunas plantas TRAMIL. Laboratorio enda-caribe, Santo Domingo, Rep. Dominicana.

5 STANDLEY PC, 1937 The flora of Costa Rica, Pt. I. Bot Serv Field Mus Nat Hist 18(391):398.

6 TOLEDO MCF, REYES FGR, IADEROZA M, FRANCIS FJ, DRAETTA IS, 1983 Anthocyanins from anil trepador (Cissus sicyoides Linn.) J Food Sci 48(4):1368-1369.

7 MARTINEZ MJ, LOPEZ M, BOUCOURT E, FUENTES V, MORON F, 2002 Evaluación de la actividad antiestafilocóccica de Cissus verticillata. Informe TRAMIL.Laboratorio Central de Farmacología, Facultad de Ciencias Médicas "Dr. Salvador Allende", La Habana, Cuba.

8 LE GRAND A, WONDERGEM PA, 1986 Activités antimicrobiennes et études bibliographiques de la toxicologie de dix plantes médicinales de la Caraïbe. Rapport TRAMIL. Dép. de Pharmacognosie, Universités de Groningen & Leyden, Hollande.

9 CAMBAR P, 1992 Efecto de los extractos acuosos de Cissus verticillata L. Informe TRAMIL. Unidad de Farmacología, Facultad de Ciencias Médicas, Universidad Nacional de Honduras UNAH, Tegucigalpa, Honduras.

10 GUARDARRAMA I, FRANCO A, ROMERO M, 1992 Estudio preliminar de las propiedades antiserotonínicas del Cissus sicyoides (Bejuco ubí). Informe TRAMIL. Instituto Superior de Ciencias Médicas, Santa Clara, Cuba. TRAMIL VI, Basse Terre, Guadeloupe, UAG/enda-caribe.

11 FENG PC, HAYNES LJ, MAGNUS KE, PLIMMER JR, 1964 Pharmacological screening of some West Indian medicinal plants. J Pharm Pharmacol 16:115-117.

12 JIU J, 1966 A survey of some medicinal plants of Mexico for selected biological activities. Lloydia 29:250-259.

13 GARCIA MD, QUILEZ AM, SAENZ MT, MARTINEZ DOMINGUEZ ME, DE LA PUERTA R, 2000.

Anti-inflammatory activity of Agave intermixta Trel. and Cissus sicyoides L., species used in South Caribbean traditional medicine.

J Ethnopharmacol 71(3): 395-400.

14 MARTINEZ MJ, LOPEZ M, BOUCOURT E, BETANCOURT J, FUENTES V, MORON F, 2002. Irritabilidad dérmica primaria de Cissus verticillata. Informe TRAMIL. Laboratorio Central de Farmacología, Facultad de Ciencias Médicas "Dr. Salvador Allende", La Habana, Cuba.

15 MARTINEZ MJ, LOPEZ M, BOUCOURT E, BETANCOURT J, FUENTES V, MORON F, 2002. Toxicidad aguda tópica de Cissus verticillata. Informe TRAMIL. Laboratorio Central de Farmacología, Facultad de Ciencias Médicas "Dr. Salvador Allende", La Habana, Cuba.

Kalanchoe pinnata


(In territories with significant traditional TRAMIL use)

 Costa Rica: leaf of life
 Guatemala: hoja del aire
 Honduras: hoja del aire
 Haiti: lou gawou , fey choche
 Martinique: zèb maltèt

Significant uses found by the TRAMIL surveys

  leaf, juice, orally5

Recommandations
Preparation and posology
References

The use as an amulet against vomiting is a traditional cultural use and is not classified in the TRAMIL program.

According to published and other information:

Use for cough is categorized as REC, based on the significant traditional use documented in the TRAMIL surveys, toxicity studies and available published scientific information.

Uses for headache and cold are categorized as REC, based on the significant traditional use documented in the TRAMIL surveys, validation, toxicity studies and available published scientific information.

Should there be a notable worsening of the patient’s condition, or should the cold last more than 2 days, seek medical attention.

Not for use during pregnancy, during lactation or in children.

For topical use for headache and oral use for cold and cough:

There is no available information establishing a means of preparation and dosage other than that referred to by traditional use.

1 WENIGER B, 1987-88
Encuesta TRAMIL. enda-caribe, Santo Domingo, Rep. Dominicana.

2 GIRON L, 1988
Encuesta TRAMIL (Costa atlántica). Centro Mesoamericano de Tecnología CEMAT, Guatemala, Guatemala.

3 LONGUEFOSSE JL, NOSSIN E, 1990-95
Enquête TRAMIL. Association pour la valorisation des plantes médicinales de la Caraïbe AVPMC, Fort de France, Martinique.

4 LAGOS-WITTE S, 1988-89, 1996
Encuesta TRAMIL. Laboratorio de Histología Vegetal y Etnobotánica, Departamento de Biología, Universidad Nacional Autónoma de Honduras UNAH, Tegucigalpa, Honduras.

5 OCAMPO R, 1988
Encuesta TRAMIL (Costa atlántica), Instituto de Desarrollo Agrario, Universidad de Costa Rica, San José, Costa Rica.

6 PINZON M, 1994
Encuesta TRAMIL (Isla de San Andrés). Laboratorio de Fitofarmacología, Departamento de Farmacología, Facultad de Salud, Universidad del Valle, Cali, Colombia.

7 WENIGER B, ROUZIER M, 1986
Enquête TRAMIL. Service Oecuménique d'Entraide SOE, Port au Prince, Haïti.

8 WENIGER B, SAVARY H, DAGUIHL R, 1984
Tri phytochimique de plantes de la liste TRAMIL. Laboratoire de chimie des substances naturelles, Faculté de Médecine et de Pharmacie, Université d'Etat d'Haïti, Port au Prince, Haïti.

9 GAIND KN, GUPTA RL, 1971
Flavonoid glycosides from Kalanchoe pinnata. Planta Med 20(4):368-373.

10 GAIND KN, GUPTA RL, 1973
Phenolic components from the leaves of Kalanchoe pinnata. Planta Med 23(12):149-153.

11 YAMAGISHI T, YAN X, WU R, MC PHAIL D, MC PHAIL A, LEE K, 1988
Structure and stereochemistry of bryophyllin-A, a novel potent cytotoxic bufadienolide orthoacetate from Bryophyllum pinnatum. Chem Pharm Bull 36(4):1615-1617.

12 YAN,XZ: LEE,KS: YAMAGISHI,T, 1992
Isolation and identification of cytotoxic components from Bryophyllum pinnatum. Shanghai Yike Daxue Xuebao 19(3):206-208.

13 AKIHISA T, KOKKE W, TAMURA T, MATSUMOTO T, 1991
Sterols of Kalanchoe pinnata: first report of the isolation of both C-24 epimers of 24-alkyl-delta-25-sterols from a higher plant. Lipids 26(8):660-665.

14 GAIND KN, GUPTA RL, 1972
Alkanes, alkanols, triterpenes and sterols from Kalanchoe pinnata. Phytochemistry 11(4):1500-1502.

15 SIDDIQUI S, FAIZI S, SIDDIQUI B, SULTANA N, 1989
Triterpenoids and phenanthrenes from leaves of Bryophyllum pinnatum. Phytochemistry 28(9):2433-2438.

16 BULEN WA, VARNER JE, BURRELL RC, 1952
Separation of organic acids from plant tissues. Anal Chem 24:187-190.

17 PAL S, SEN T, CHAUDHURI AK, 1999
Neuropsychopharmacological profile of the methanolic fraction of Bryophyllum pinnatum leaf extract. J Pharm Pharmacol 51(3):313-318.

18 MORAES V, COSTA S, BERGMANN R, 1992
Immunomodulatory activity of Brazilian medicinal plants. Dept. of Biochemistry, ICB, URFJ, Rio de Janeiro, Brasil.

19 OBASEIKI-EBOR EE, 1985
Preliminary report on the in vitro antibacterial activity of Bryophyllum pinnatum leaf juice. Afr J Med Sci 14(3-4):199-202.

20 SINGH K, PATHAK R, 1984
Effect of leaves extracts of some higher plants on spore germination of Ustilago maydes and U. nuda. Fitoterapia 55(5):318-320.

21 NAOVI S, KHAN M, VOHORA S, 1991
Antibacterial, antifungal and anthelmintic investigation on Indian medicinal plants. Fitoterapia 62(3):21-228.

22 HEMA D, TIDJANI M, BASSENE E, POUSSET JL, GIONO-BARBER H, 1986
African medicinal plants. XXIV. Study of the antiinflammatory activity of Bryophyllum pinnatum. Plant Med Phytother 20(3):231-235.

23 FENG P, HAYNES L, MAGNUS K, PLIMMER J, SHERRAT H, 1962
Pharmacological screening of some West Indian medicinal plants. J Pharm Pharmacol 14:556-561.

24 ANDRONOVA L, 1972
Antitussive properties of certain medical plants. Rast Resur 8:588-591.

25 BERSHTEJN E, 1972
Utilisation du jus de Kalanchoe pinnata dans le traitement des ulcères trophiques de la jambe. Vest Khir URSS 108(3):116-118.

26SVANIDZE N, LANOVENKLY V, SÁNCHEZ A, RODRÍGUEZ P, 1975
Kalanchoe pinnata como planta medicinal en Cuba. Rev Cub Farm 9(3):225-228.

27 YAMAGISHI T, HARUNA M, YAN XZ, CHANG JJ, LEE KH, 1989
Antitumor agents. 110. Bryophylline B., a novel potent cytotoxic bufadienolide from Bryophyllum pinnatum. J Nat Prod 52(5):1071-1079.

28 BOAKYE-YIADOM K, 1977
Antimicrobial properties of some West African medicinal plants. 1. Antimicrobial action of Bryophyllum pinnatum. Quart J Crude Res 15:201-202.

29 PERRY LM, METZGER J, 1980
Medicinal plants of East and Southeast Asia: attributed properties and uses. Cambridge, USA: MIT Press.

30 DUKE JA, 1992
Handbook of biologically active phytochemicals and their bioactivities. Boca Raton, USA: CRC Press.

31 DUKE JA, 1992
Handbook of phytochemical constituents of GRAS Herbs and other economic plants. Boca Raton, USA: CRC Press.

32 OLIVER B, 1960
Medicinal plants in Nigeria. Ibadan, Nigeria: Nigerian College of Arts, Science and Technology.

33 PAZOS L, COTO T, GONZALEZ S, 2003
Toxicidad oral, aguda en ratones, de la hoja de Kalanchoe pinnata. Informe TRAMIL. Laboratorio de Ensayos Biológicos, Universidad de Costa Rica, San Pedro, Costa Rica.

34 PAZOS L, COTO T, GONZALEZ S, 2003
Toxicidad oral, aguda en ratones, del extracto acuoso del zumo de la hoja de Kalanchoe pinnata. Informe TRAMIL. Laboratorio de Ensayos Biológicos, Universidad de Costa Rica, San Pedro, Costa Rica.

35 PAZOS L, COTO T, GONZALEZ S, 2003
Estudio de irritabilidad dérmica, en piel lesionada de conejo, de hoja fresca machacada de Kalanchoe pinnata. Informe TRAMIL.Laboratorio de Ensayos Biológicos, Universidad de Costa Rica, San Pedro, Costa Rica.

36 YOKEL R, OGZEWALLA CD, 1981
Effects of plant ingestion in rats determined by the conditioned taste aversion procedure. Toxicon 19(2):223-232.

37 BHAKUNI O, DHAR ML, DHAR MM, DHAWAN BN, MEHROTRA BN, 1969
Screening of Indian plants for biological activity. Part II. Indian J Exp Biol 7:250-262.

38 PAL S, SEN T, CHAUDHURI AKN,1999
Neuropsychopharmacological profile of the methanolic fraction of Bryophyllum pinnatum leaf extract. J Pharm Pharmacol 51(3):313-318.

39 REPPAS GP, 1995
Bryophyllum pinnatum poisoning of cattle. Aust Vet J 72(11):425-427.

40 MCKENZIE RA, FRANKE FP, DUNSTER PJ, 1987
The toxicity to cattle and bufadienolide content of six Bryophyllum species. Aust Vet J 64(10):298-301.